Harmonica virtuoso Little Walter was a key contributor to bluesman Muddy Waters' music through most of the 1950s. Both as a sideman and bandleader, Little Walter revolutionised the sound of blues harmonica through amplification, clasping a mike to the harp as he played.

His daring instrumental innovations were fresh, startling, and ahead of their time. The Best of Little Walter was his debut LP. First released in 1957, this compilation album contained ten Little Walter songs that appeared in the Top 10 of Billboard's R&B chart from 1952 to 1955, plus two B-sides.